Tell sufferers that a domestic teaspoon is not really an accurate measuring system and such use may lead to overdosage and severe adverse reactions [see OVERDOSAGE (10)]. For prescriptions exactly where a measuring device will not be offered, a pharmacist can provide an ideal calibrated measuring machine and can provide Recommendations for measuring the right dose.
Constipation is a common aspect influence of each codeine and hydrocodone use and sometimes continues throughout remedy. People may perhaps choose stool softeners and maximize their fluid consumption to assist cut down this aspect impact.
Promethazine might lead to other Unwanted side effects. Call your physician when you encounter any unusual issues when you are getting this medication.
Consulting with toxicology and nephrology pertaining to even further administration, as many as and which include dialysis
By way of example, a lot of described situations of Dying occurred during the publish-operative period adhering to tonsillectomy and/or adenoidectomy, and many of the children had evidence of getting ultra-rapid metabolizers of codeine. Furthermore, little ones with obstructive rest apnea who are addressed with codeine for write-up-tonsillectomy and/or adenoidectomy soreness may be particularly delicate to its respiratory depressant outcome. Due to the threat of everyday living-threatening respiratory melancholy and Demise:
Checking the client for symptoms and/or signs or symptoms of respiratory despair, cardiac arrhythmias, and narcotic bowel syndrome
To lessen the chance of dizziness and lightheadedness, stand up bit by bit when increasing from the sitting down or lying posture.
The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are advanced.
Constipation is one of the most frequent adverse outcomes of codeine. Most individuals report some constipation pursuing the initiation of therapy or boosts in dose. With ongoing publicity, constipation remains a persistent destructive effect with the drug.
Browse the Medication Information supplied by your pharmacist before you start taking promethazine/phenylephrine/codeine and each time you will get a refill. When you've got any questions, talk to your doctor or pharmacist.
When codeine is utilised for some time or in large doses, it may come to be habit-forming, causing psychological or Bodily dependence. Physical dependence may well cause withdrawal Negative effects when you quickly stop taking the medicine.
It is very important that the health care provider Check out your or your son or daughter's progress when employing this drugs. This enables your medical doctor to see In case the medication is Performing effectively and to come to a decision when you or your child should continue on to just take it. Blood tests can be required to check for unwanted effects.
Carcinogenicity experiments were conducted with promethazine hydrochloride. Two-year scientific studies in F344/N rats and B6C3F1 mice were carried Promethazine codeine syrup out to assess the carcinogenic potential of promethazine hydrochloride. No evidence of tumorigenicity was noticed in male and female rats at promethazine hydrochloride oral doses approximately 33 mg/kg/day for 5 days/7 days (somewhere around such as 10 instances the MRHD on a mg/m2 basis).
Promethazine with Codeine Oral Solution isn't advisable for use in pregnant Females. Extended usage of Promethazine with Codeine Oral Resolution during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in Older people, can be existence-threatening Otherwise identified and handled, and necessitates administration In keeping with protocols made by neonatology specialists.